Assay Detail
Functional
CHEMBL4391975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.62 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464660 | — | — | 1 | 10.05 |
| CHEMBL4457749 | — | — | 1 | 9.30 |
| CHEMBL4465617 | — | — | 1 | 9.19 |
| CHEMBL4513569 | — | — | 1 | 9.12 |
| CHEMBL4457910 | — | — | 1 | 8.96 |
| CHEMBL4436307 | — | — | 1 | 8.85 |
| CHEMBL4472705 | — | — | 1 | 8.54 |
| CHEMBL4532218 | — | — | 1 | 8.47 |
| CHEMBL4467034 | — | — | 1 | 8.43 |
| CHEMBL4544660 | — | — | 1 | 8.26 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.19 |
| CHEMBL4573274 | — | — | 1 | 8.11 |
| CHEMBL4437915 | — | — | 1 | 7.90 |
| CHEMBL4438847 | — | — | 1 | 7.83 |
| CHEMBL4553286 | — | — | 1 | 7.77 |
| CHEMBL4586210 | — | — | 1 | 7.32 |
| CHEMBL4471348 | — | — | 1 | 7.14 |
| CHEMBL4571858 | — | — | 1 | 7.07 |
| CHEMBL4591302 | — | — | 1 | 7.00 |
| CHEMBL4547527 | — | — | 1 | 6.95 |
| CHEMBL4553690 | — | — | 1 | 6.92 |
| CHEMBL4569227 | — | — | 1 | 6.86 |
| CHEMBL4435084 | — | — | 1 | 6.74 |
| CHEMBL4444991 | — | — | 1 | 6.70 |
| CHEMBL4563655 | — | — | 1 | 6.66 |
| CHEMBL4463297 | — | — | 1 | 6.44 |
| CHEMBL4531725 | — | — | 1 | 6.36 |
| CHEMBL4471398 | — | — | 1 | 6.34 |
| CHEMBL4517159 | — | — | 1 | 6.30 |
| CHEMBL4517602 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464660 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL4457749 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4465617 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4513569 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL4457910 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4436307 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4472705 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4532218 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4467034 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4544660 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4573274 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4437915 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL4438847 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL4553286 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4586210 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4471348 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4571858 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4591302 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4547527 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4553690 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4569227 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL4435084 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4444991 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL4563655 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4463297 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL4531725 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL4471398 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL4517159 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL4517602 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL4544761 | — | IC50 | = | 793.0 | nM | 6.10 |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 31262.0 | nM | - |