Assay Detail
ADMET
CHEMBL4392168
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Displacement of [3H](R)-(+)-7-OH-DPAT from human D2L receptor expressed in HEK293 cell membranes measured after 90 mins by scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.35 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464861 | — | — | 1 | 7.09 |
| CHEMBL216393 | — | — | 1 | 6.90 |
| CHEMBL4473652 | — | — | 1 | 6.70 |
| CHEMBL4454068 | — | — | 1 | 6.70 |
| CHEMBL375596 | — | — | 1 | 6.60 |
| CHEMBL4442548 | — | — | 1 | 6.22 |
| CHEMBL4588808 | — | — | 1 | 5.83 |
| CHEMBL4443054 | — | — | 1 | 5.62 |
| CHEMBL4448320 | — | — | 1 | 5.48 |
| CHEMBL4587925 | — | — | 1 | - |
| CHEMBL4572245 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464861 | — | Ki | = | 80.3 | nM | 7.09 |
| CHEMBL216393 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL4473652 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4454068 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL375596 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL4442548 | — | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL4588808 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL4443054 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL4448320 | — | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL4587925 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4572245 | — | Ki | > | 10000.0 | nM | - |