Assay Detail
Binding
CHEMBL4392170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](R)-(+)-7-OH-DPAT from human D4.4 receptor expressed in HEK293 cell membranes measured after 90 mins by scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.16 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216393 | — | — | 1 | 8.85 |
| CHEMBL4473652 | — | — | 1 | 8.78 |
| CHEMBL4448320 | — | — | 1 | 8.72 |
| CHEMBL4442548 | — | — | 1 | 8.65 |
| CHEMBL375596 | — | — | 1 | 8.40 |
| CHEMBL4443054 | — | — | 1 | 8.25 |
| CHEMBL4587925 | — | — | 1 | 8.16 |
| CHEMBL4572245 | — | — | 1 | 7.90 |
| CHEMBL4454068 | — | — | 1 | 7.49 |
| CHEMBL4588808 | — | — | 1 | 7.48 |
| CHEMBL4464861 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216393 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4473652 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL4448320 | — | Ki | = | 1.89 | nM | 8.72 |
| CHEMBL4442548 | — | Ki | = | 2.23 | nM | 8.65 |
| CHEMBL375596 | — | Ki | = | 3.95 | nM | 8.40 |
| CHEMBL4443054 | — | Ki | = | 5.66 | nM | 8.25 |
| CHEMBL4587925 | — | Ki | = | 6.87 | nM | 8.16 |
| CHEMBL4572245 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL4454068 | — | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL4588808 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4464861 | — | Ki | = | 76.4 | nM | 7.12 |