Assay Detail
ADMET
CHEMBL4392174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.24 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464861 | — | — | 1 | 7.30 |
| CHEMBL4454068 | — | — | 1 | 6.81 |
| CHEMBL4448320 | — | — | 1 | 6.12 |
| CHEMBL4442548 | — | — | 1 | 5.80 |
| CHEMBL4592753 | — | — | 1 | 5.71 |
| CHEMBL4443054 | — | — | 1 | 5.68 |
| CHEMBL216393 | — | — | 1 | - |
| CHEMBL4473792 | — | — | 1 | - |
| CHEMBL4436479 | — | — | 1 | - |
| CHEMBL4587925 | — | — | 1 | - |
| CHEMBL4572245 | — | — | 1 | - |
| CHEMBL4473652 | — | — | 1 | - |
| CHEMBL4588808 | — | — | 1 | - |
| CHEMBL4437912 | — | — | 1 | - |
| CHEMBL4443848 | — | — | 1 | - |
| CHEMBL4591118 | — | — | 1 | - |
| CHEMBL4453069 | — | — | 1 | - |
| CHEMBL375596 | — | — | 1 | - |
| CHEMBL4456754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464861 | — | EC50 | = | 50.1 | nM | 7.30 |
| CHEMBL4454068 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4448320 | — | EC50 | = | 763.0 | nM | 6.12 |
| CHEMBL4442548 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4592753 | — | EC50 | = | 1965.0 | nM | 5.71 |
| CHEMBL4443054 | — | EC50 | = | 2092.0 | nM | 5.68 |
| CHEMBL216393 | — | EC50 | - | — | - | |
| CHEMBL4473792 | — | EC50 | - | — | - | |
| CHEMBL4436479 | — | EC50 | - | — | - | |
| CHEMBL4587925 | — | EC50 | - | — | - | |
| CHEMBL4572245 | — | EC50 | - | — | - | |
| CHEMBL4473652 | — | EC50 | - | — | - | |
| CHEMBL4588808 | — | EC50 | - | — | - | |
| CHEMBL4437912 | — | EC50 | - | — | - | |
| CHEMBL4443848 | — | EC50 | - | — | - | |
| CHEMBL4591118 | — | EC50 | - | — | - | |
| CHEMBL4453069 | — | EC50 | - | — | - | |
| CHEMBL375596 | — | EC50 | - | — | - | |
| CHEMBL4456754 | — | EC50 | - | — | - |