Assay Detail
Binding
CHEMBL4392268
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Inhibition of CD73 in human MDA-MB-231 cell membranes using [2,8-3H]AMP as substrate measured after 25 mins by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.11 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3606064 | — | — | 1 | 8.35 |
| CHEMBL4483379 | — | — | 1 | 8.25 |
| CHEMBL4443094 | — | — | 1 | 8.20 |
| CHEMBL4443977 | — | — | 1 | 8.10 |
| CHEMBL4551648 | — | — | 1 | 8.00 |
| CHEMBL4470616 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3606064 | — | Ki | = | 4.51 | nM | 8.35 |
| CHEMBL4483379 | — | Ki | = | 5.68 | nM | 8.25 |
| CHEMBL4443094 | — | Ki | = | 6.29 | nM | 8.20 |
| CHEMBL4443977 | — | Ki | = | 7.96 | nM | 8.10 |
| CHEMBL4551648 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL4470616 | — | Ki | = | 16.6 | nM | 7.78 |