Assay Detail
Binding
CHEMBL4392471
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Inhibition of HIV1 protease activity
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.49 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 9.52 |
| CHEMBL4300203 | — | — | 1 | 8.40 |
| CHEMBL4522729 | — | — | 1 | 8.40 |
| CHEMBL4437104 | — | — | 1 | 8.40 |
| CHEMBL4474072 | — | — | 1 | 8.40 |
| CHEMBL4460401 | — | — | 1 | 8.40 |
| CHEMBL4554438 | — | — | 1 | 8.40 |
| CHEMBL4447493 | — | — | 1 | 8.40 |
| CHEMBL4463796 | — | — | 1 | 8.40 |
| CHEMBL4525849 | — | — | 1 | 8.40 |
| CHEMBL4542773 | — | — | 1 | 8.40 |
| CHEMBL4573907 | — | — | 1 | 8.40 |
| CHEMBL4574382 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4300203 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4522729 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4437104 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4474072 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4460401 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4554438 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4447493 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4463796 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4525849 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4542773 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4573907 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4574382 | — | IC50 | = | 4.0 | nM | 8.40 |