Assay Detail
Functional
CHEMBL4392526
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Growth inhibition of human HCT116/VM46 cells measured after 72 hrs by phosphatase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116/VM46 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.36 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454735 | — | — | 1 | 9.08 |
| CHEMBL4442023 | — | — | 1 | 9.06 |
| CHEMBL4472320 | — | — | 1 | 9.06 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454735 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL4442023 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4472320 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 600.0 | nM | 6.22 |