Assay Detail

CHEMBL4392558

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Functional

Antiproliferative activity against human Z138 cells

ChEMBL ↗

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Target

Z-138 (CHEMBL4483276) ↗

Open DB target context

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Primary target Z-138

CHEMBL4483276

Anchored from Assay target.

Protein identity Z-138

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Z-138
Confidence	1 — Organism
Curated By	Autocuration

Target

Z-138 (CHEMBL4483276) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors.

Lin H, Luengo JI.
Bioorg Med Chem Lett (2019) 29 : 1264 -1269
PubMed 30956011 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.85	8.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4441584	—	—	1	8.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4441584	—	IC50	=	1.4	nM	8.85