Assay Detail
Functional
CHEMBL4392559
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Antiproliferative activity against human GRANTA-519 cells incubated for 3 days and measured upto 10 days by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Granta-519 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.95 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536042 | — | — | 1 | 7.01 |
| CHEMBL4465375 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536042 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4465375 | — | IC50 | = | 131.0 | nM | 6.88 |