Assay Detail
Functional
CHEMBL4392563
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Antiproliferative activity against human A549 cells
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.00 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4547524 | — | — | 1 | 8.70 |
| CHEMBL4455651 | — | — | 2 | 8.70 |
| CHEMBL4563402 | — | — | 1 | 8.15 |
| CHEMBL4541232 | — | — | 1 | 6.92 |
| CHEMBL4470815 | — | — | 1 | 6.85 |
| CHEMBL4445368 | — | — | 1 | 6.71 |
| CHEMBL4517481 | — | — | 1 | 6.46 |
| CHEMBL4460647 | — | — | 1 | 6.42 |
| CHEMBL4579108 | — | — | 1 | 6.02 |
| CHEMBL4585734 | — | — | 1 | 5.79 |
| CHEMBL4448266 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4547524 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4455651 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4563402 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4455651 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4541232 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4470815 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4445368 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4517481 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4460647 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL4579108 | — | IC50 | = | 948.0 | nM | 6.02 |
| CHEMBL4585734 | — | IC50 | = | 1615.0 | nM | 5.79 |
| CHEMBL4448266 | — | IC50 | = | 3822.0 | nM | 5.42 |