Assay Detail
Functional
CHEMBL4392615
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin reagent based fluorescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New analogs of SYA013 as sigma-2 ligands with anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.89 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4566049 | — | — | 1 | 5.16 |
| CHEMBL476108 | — | — | 1 | 4.82 |
| CHEMBL1946124 | — | — | 1 | 4.70 |
| CHEMBL4558031 | — | — | 1 | - |
| CHEMBL4467840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4566049 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL476108 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1946124 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4558031 | — | IC50 | - | — | - | |
| CHEMBL4467840 | — | IC50 | - | — | - |