Assay Detail
Binding
CHEMBL4392737
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Binding affinity to influenza virus PB2 transformed into Escherichia coli rosseta competent cells by surface plasmon resonance analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | unidentified influenza virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one derivatives as new potent PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 31 | 5.80 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 7.16 |
| CHEMBL4469834 | — | — | 1 | 6.96 |
| CHEMBL4443461 | — | — | 1 | 6.80 |
| CHEMBL4452795 | — | — | 1 | 6.77 |
| CHEMBL4456599 | — | — | 1 | 6.57 |
| CHEMBL4435164 | — | — | 1 | 6.50 |
| CHEMBL4563743 | — | — | 1 | 6.50 |
| CHEMBL4532059 | — | — | 1 | 6.33 |
| CHEMBL4457333 | — | — | 1 | 6.31 |
| CHEMBL4566862 | — | — | 1 | 6.30 |
| CHEMBL4529774 | — | — | 1 | 6.28 |
| CHEMBL4551918 | — | — | 1 | 6.13 |
| CHEMBL4573532 | — | — | 1 | 6.00 |
| CHEMBL4550597 | — | — | 1 | 5.98 |
| CHEMBL4583902 | — | — | 1 | 5.69 |
| CHEMBL4461251 | — | — | 1 | 5.67 |
| CHEMBL4450201 | — | — | 1 | 5.46 |
| CHEMBL4559625 | — | — | 1 | 5.41 |
| CHEMBL4558110 | — | — | 1 | 5.31 |
| CHEMBL4473584 | — | — | 1 | 5.28 |
| CHEMBL4483430 | — | — | 1 | 5.27 |
| CHEMBL4466238 | — | — | 1 | 5.21 |
| CHEMBL4554843 | — | — | 1 | 5.15 |
| CHEMBL4438915 | — | — | 1 | 5.08 |
| CHEMBL4587854 | — | — | 1 | 4.99 |
| CHEMBL4525831 | — | — | 1 | 4.99 |
| CHEMBL4440949 | — | — | 1 | 4.79 |
| CHEMBL4536814 | — | — | 1 | 4.65 |
| CHEMBL4573311 | — | — | 1 | 4.59 |
| CHEMBL4527087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | Kd | = | 70.0 | nM | 7.16 |
| CHEMBL4469834 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL4443461 | — | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL4452795 | — | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL4456599 | — | Kd | = | 270.0 | nM | 6.57 |
| CHEMBL4435164 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL4563743 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL4532059 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4457333 | — | Kd | = | 490.0 | nM | 6.31 |
| CHEMBL4566862 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4529774 | — | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL4551918 | — | Kd | = | 740.0 | nM | 6.13 |
| CHEMBL4573532 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL4550597 | — | Kd | = | 1040.0 | nM | 5.98 |
| CHEMBL4583902 | — | Kd | = | 2050.0 | nM | 5.69 |
| CHEMBL4461251 | — | Kd | = | 2130.0 | nM | 5.67 |
| CHEMBL4450201 | — | Kd | = | 3470.0 | nM | 5.46 |
| CHEMBL4559625 | — | Kd | = | 3930.0 | nM | 5.41 |
| CHEMBL4558110 | — | Kd | = | 4900.0 | nM | 5.31 |
| CHEMBL4473584 | — | Kd | = | 5230.0 | nM | 5.28 |
| CHEMBL4483430 | — | Kd | = | 5330.0 | nM | 5.27 |
| CHEMBL4466238 | — | Kd | = | 6230.0 | nM | 5.21 |
| CHEMBL4554843 | — | Kd | = | 7150.0 | nM | 5.15 |
| CHEMBL4438915 | — | Kd | = | 8270.0 | nM | 5.08 |
| CHEMBL4587854 | — | Kd | = | 10270.0 | nM | 4.99 |
| CHEMBL4525831 | — | Kd | = | 10230.0 | nM | 4.99 |
| CHEMBL4440949 | — | Kd | = | 16330.0 | nM | 4.79 |
| CHEMBL4536814 | — | Kd | = | 22330.0 | nM | 4.65 |
| CHEMBL4573311 | — | Kd | = | 25670.0 | nM | 4.59 |
| CHEMBL4527087 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL4587630 | — | Kd | > | 50000.0 | nM | - |