Assay Detail
Binding
CHEMBL4392738
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Binding affinity to influenza virus PB2 transformed into Escherichia coli rosseta competent cells by isothermal titration calorimetry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | unidentified influenza virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one derivatives as new potent PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.01 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 7.30 |
| CHEMBL4469834 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL4469834 | — | Kd | = | 190.0 | nM | 6.72 |