Assay Detail
Binding
CHEMBL4392763
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Inhibition of recombinant human GSK3beta using prephosphorylated peptide as substrate measured after 30 mins by Kinase-glo luminescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.23 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259850 | — | — | 1 | 7.14 |
| CHEMBL4447545 | — | — | 1 | 7.07 |
| CHEMBL1824333 | — | — | 1 | 6.96 |
| CHEMBL4546384 | — | — | 1 | 6.89 |
| CHEMBL4452731 | — | — | 1 | 6.58 |
| CHEMBL4532931 | — | — | 1 | 6.11 |
| CHEMBL4516941 | — | — | 1 | 5.74 |
| CHEMBL4452831 | — | — | 1 | 5.65 |
| CHEMBL4556827 | — | — | 1 | 5.61 |
| CHEMBL4573681 | — | — | 1 | 5.39 |
| CHEMBL4571262 | — | — | 1 | 5.38 |
| CHEMBL4437756 | — | — | 1 | - |
| CHEMBL4461606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259850 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4447545 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1824333 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4546384 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4452731 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4532931 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4516941 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4452831 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4556827 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4573681 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4571262 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL4437756 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4461606 | — | IC50 | > | 10000.0 | nM | - |