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Assay Detail

CHEMBL4392898

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at TLR2 in human cells by cell based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Toll-like receptor 2 (CHEMBL4163)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.
Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EMY, Boger DL, Beutler B, Zhang H.
J Med Chem (2019) 62 : 2938 -2949
PubMed 30829478 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 9.96 9.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4472879 1 9.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4472879 EC50 = 0.11 nM 9.96