Assay Detail
Binding
CHEMBL4392953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kv1.5 in human atrial myocytes assessed as blockade of Ikur current
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 5 (CHEMBL4306) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.74 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475999 | — | — | 1 | 7.22 |
| CHEMBL4451245 | — | — | 1 | 6.58 |
| CHEMBL4527638 | — | — | 1 | 6.41 |
| CHEMBL4437013 | — | — | 1 | - |
| CHEMBL4453132 | — | — | 1 | - |
| CHEMBL4466634 | — | — | 1 | - |
| CHEMBL4539540 | — | — | 1 | - |
| CHEMBL4517112 | — | — | 1 | - |
| CHEMBL4474540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475999 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4451245 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4527638 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4437013 | — | IC50 | - | — | - | |
| CHEMBL4453132 | — | IC50 | - | — | - | |
| CHEMBL4466634 | — | IC50 | - | — | - | |
| CHEMBL4539540 | — | IC50 | - | — | - | |
| CHEMBL4517112 | — | IC50 | - | — | - | |
| CHEMBL4474540 | — | IC50 | - | — | - |