Assay Detail
Functional
CHEMBL4392979
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Cytotoxicity against human MDA-MB-468 cells incubated for 4 hrs under hypoxic condition followed by compound washout and measured after 5 days by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.93 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 8.21 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 6.09 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.88 |
| CHEMBL4471736 | — | — | 1 | 5.13 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 4.34 |
| CHEMBL4591106 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL852 | MELPHALAN | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 1304.0 | nM | 5.88 |
| CHEMBL4471736 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 45530.0 | nM | 4.34 |
| CHEMBL4591106 | — | IC50 | = | 247960.0 | nM | - |