Assay Detail
Binding
CHEMBL4393412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAOA using kynuramine as substrate incubated for 10 mins by UPLC-ESI-MS/MS analysis
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.51 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 7.60 |
| CHEMBL4549753 | — | — | 1 | 7.22 |
| CHEMBL4448210 | — | — | 1 | 6.85 |
| CHEMBL4539671 | — | — | 1 | 6.70 |
| CHEMBL4450374 | — | — | 1 | 6.70 |
| CHEMBL4526304 | — | — | 1 | 6.52 |
| CHEMBL4593138 | — | — | 1 | 6.10 |
| CHEMBL4581266 | — | — | 1 | 5.96 |
| CHEMBL4530047 | — | — | 1 | 5.68 |
| CHEMBL4559886 | — | — | 1 | 5.66 |
| CHEMBL4555193 | — | — | 1 | 5.57 |
| CHEMBL4462827 | — | — | 1 | 5.54 |
| CHEMBL4544217 | — | — | 1 | 5.52 |
| CHEMBL4465226 | — | — | 1 | 5.50 |
| CHEMBL4517254 | — | — | 1 | 5.42 |
| CHEMBL4455693 | — | — | 1 | 5.39 |
| CHEMBL4467171 | — | — | 1 | 5.39 |
| CHEMBL4532802 | — | — | 1 | 5.36 |
| CHEMBL4441284 | — | — | 1 | 5.35 |
| CHEMBL461985 | — | — | 1 | 5.34 |
| CHEMBL499303 | (-)-(R)-MELLEIN | — | 1 | 5.21 |
| CHEMBL4438912 | — | — | 1 | 5.12 |
| CHEMBL4453404 | — | — | 1 | 5.10 |
| CHEMBL4547510 | — | — | 1 | 4.98 |
| CHEMBL4527486 | — | — | 1 | 4.91 |
| CHEMBL4466358 | — | — | 1 | 4.87 |
| CHEMBL4483744 | — | — | 1 | 4.86 |
| CHEMBL4585681 | — | — | 1 | 4.80 |
| CHEMBL4465443 | — | — | 1 | 4.80 |
| CHEMBL4475937 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4549753 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4448210 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4539671 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4450374 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4526304 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4593138 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4581266 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4530047 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4559886 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4555193 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4462827 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4544217 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4465226 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4517254 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4455693 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4467171 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4532802 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4441284 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL461985 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL499303 | (-)-(R)-MELLEIN | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4438912 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4453404 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4547510 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4527486 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4466358 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4483744 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4585681 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4465443 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4475937 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4533460 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4451312 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4525433 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4515749 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL4525616 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4584605 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4482938 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL673 | PARGYLINE | IC50 | - | — | - | |
| CHEMBL4463607 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4556318 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4470661 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4474942 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4435462 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4471980 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4469254 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4586304 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4534960 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4568562 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4575872 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4449959 | — | IC50 | > | 50000.0 | nM | - |