Assay Detail
Functional
CHEMBL4393479
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Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.59 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459598 | — | — | 1 | 9.00 |
| CHEMBL4451053 | — | — | 1 | 8.96 |
| CHEMBL4435499 | — | — | 1 | 8.92 |
| CHEMBL4436031 | — | — | 1 | 8.89 |
| CHEMBL1080066 | 16-HYDROXY VERRUCARIN A | — | 1 | 8.77 |
| CHEMBL136985 | VERRUCARIN A | — | 1 | 8.52 |
| CHEMBL4555484 | — | — | 1 | 8.19 |
| CHEMBL334648 | RORIDIN A | — | 1 | 8.15 |
| CHEMBL4544523 | — | — | 1 | 7.25 |
| CHEMBL4551089 | — | — | 1 | 6.29 |
| CHEMBL509175 | RORIDIN E | — | 1 | 6.27 |
| CHEMBL4449215 | — | — | 1 | 6.04 |
| CHEMBL4459838 | — | — | 1 | 6.01 |
| CHEMBL4463340 | — | — | 1 | 5.82 |
| CHEMBL4515580 | — | — | 1 | 5.54 |
| CHEMBL4567360 | — | — | 1 | 5.50 |
| CHEMBL447144 | — | — | 1 | 5.15 |
| CHEMBL4566134 | — | — | 1 | 5.09 |
| CHEMBL4513960 | — | — | 1 | 4.80 |
| CHEMBL4465899 | — | — | 1 | 4.80 |
| CHEMBL4544860 | — | — | 1 | 4.57 |
| CHEMBL4444618 | — | — | 1 | 4.50 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459598 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4451053 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4435499 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4436031 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1080066 | 16-HYDROXY VERRUCARIN A | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL136985 | VERRUCARIN A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4555484 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL334648 | RORIDIN A | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4544523 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4551089 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL509175 | RORIDIN E | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4449215 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4459838 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4463340 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4515580 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4567360 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL447144 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL4566134 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4513960 | — | IC50 | = | 15980.0 | nM | 4.80 |
| CHEMBL4465899 | — | IC50 | = | 15950.0 | nM | 4.80 |
| CHEMBL4544860 | — | IC50 | = | 26690.0 | nM | 4.57 |
| CHEMBL4444618 | — | IC50 | = | 31590.0 | nM | 4.50 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 32920.0 | nM | 4.48 |