Assay Detail
Functional
CHEMBL4393514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549 cells measured after 72 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic Tigliane Diterpenoids from Croton damayeshu.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.62 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.40 |
| CHEMBL4551600 | — | — | 1 | 6.05 |
| CHEMBL4547006 | — | — | 1 | 5.89 |
| CHEMBL2375779 | — | — | 1 | 5.72 |
| CHEMBL4592818 | — | — | 1 | 5.43 |
| CHEMBL4514467 | — | — | 1 | 5.39 |
| CHEMBL4466266 | — | — | 1 | 5.34 |
| CHEMBL4459849 | — | — | 1 | 4.74 |
| CHEMBL4534646 | — | — | 1 | - |
| CHEMBL4444562 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4551600 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4547006 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2375779 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4592818 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4514467 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4466266 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4459849 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4534646 | — | IC50 | - | — | - | |
| CHEMBL4444562 | — | IC50 | - | — | - |