Assay Detail
Binding
CHEMBL4393529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NaV in mouse Neuro2a cells assessed as suppression of ouabain/veratridine-induced reduction in cell viability measured after 20 hrs by WST8 assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Isolation and Biological Activity of 8- Epitetrodotoxin and the Structure of a Possible Biosynthetic Shunt Product of Tetrodotoxin, Cep-226A, from the Newt Cynops ensicauda popei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| EC50 | 3 | 7.72 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | 3.0 | 2 | 8.72 |
| CHEMBL4515943 | — | — | 2 | 7.48 |
| CHEMBL4208190 | — | — | 2 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4515943 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4208190 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4515943 | — | Inhibition | - | % | - | |
| CHEMBL4208190 | — | Inhibition | - | % | - | |
| CHEMBL507974 | TETRODOTOXIN | Inhibition | - | % | - |