Assay Detail
Binding
CHEMBL4393749
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Inhibition of HIV1 reverse transcriptase
22
Total Activities
20
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 11 | - | - |
| IC50 | 10 | 7.00 | 8.22 |
| Ki | 1 | 8.53 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 3 | 8.53 |
| CHEMBL3753096 | — | — | 1 | 8.22 |
| CHEMBL309896 | — | — | 1 | 7.92 |
| CHEMBL311996 | — | — | 1 | 7.63 |
| CHEMBL4436313 | — | — | 1 | 7.34 |
| CHEMBL4483481 | — | — | 1 | 7.25 |
| CHEMBL4529500 | — | — | 1 | 7.09 |
| CHEMBL3753006 | — | — | 1 | 6.10 |
| CHEMBL3754170 | — | — | 1 | 6.02 |
| CHEMBL311050 | — | — | 1 | 5.03 |
| CHEMBL4560835 | — | — | 1 | - |
| CHEMBL3752646 | — | — | 1 | - |
| CHEMBL102668 | — | — | 1 | - |
| CHEMBL273285 | — | — | 1 | - |
| CHEMBL318000 | — | — | 1 | - |
| CHEMBL101024 | — | — | 1 | - |
| CHEMBL330659 | — | — | 1 | - |
| CHEMBL103395 | — | — | 1 | - |
| CHEMBL101881 | — | — | 1 | - |
| CHEMBL100518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | Ki | = | 2.93 | nM | 8.53 |
| CHEMBL3753096 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL309896 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL311996 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4436313 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4483481 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4529500 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3753006 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3754170 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL311050 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4560835 | — | IC90 | = | 279.09 | nM | - |
| CHEMBL223228 | EFAVIRENZ | IC90 | = | 1.7 | nM | - |
| CHEMBL3752646 | — | IC90 | = | 295.6 | nM | - |
| CHEMBL100518 | — | IC90 | = | 9.02 | nM | - |
| CHEMBL102668 | — | IC90 | = | 2.0 | nM | - |
| CHEMBL273285 | — | IC90 | = | 7.11 | nM | - |
| CHEMBL318000 | — | IC90 | = | 7.35 | nM | - |
| CHEMBL101024 | — | IC90 | = | 10.31 | nM | - |
| CHEMBL330659 | — | IC90 | = | 18.89 | nM | - |
| CHEMBL103395 | — | IC90 | = | 20.59 | nM | - |
| CHEMBL101881 | — | IC90 | = | 8.33 | nM | - |