Assay Detail
Binding
CHEMBL4393751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 reverse transcriptase derived from HIV patient plasma by LC/MS/MS analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.62 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37628 | — | — | 1 | 7.46 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.08 |
| CHEMBL37343 | — | — | 1 | 6.90 |
| CHEMBL306032 | — | — | 1 | 6.46 |
| CHEMBL307792 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37628 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL37343 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL306032 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL307792 | — | IC50 | = | 6000.0 | nM | 5.22 |