Assay Detail
Binding
CHEMBL4393770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.38 | 9.10 |
| Ki | 1 | 10.10 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434674 | — | — | 1 | 10.10 |
| CHEMBL4541013 | — | — | 1 | 9.10 |
| CHEMBL4576860 | — | — | 1 | 8.70 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434674 | — | Ki | = | 0.07943 | nM | 10.10 |
| CHEMBL4541013 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL4576860 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 45.0 | nM | 7.35 |