Assay Detail
Functional
CHEMBL4393889
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Antileishmanial activity against promastigote stage of Leishmania donovani MHOM/ET/67/HU3 assessed as parasite growth inhibition after 3 days by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.52 |
| CHEMBL4566866 | — | — | 1 | 6.42 |
| CHEMBL4467147 | — | — | 1 | 5.80 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.72 |
| CHEMBL4559932 | — | — | 1 | 5.60 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 5.39 |
| CHEMBL4448415 | — | — | 1 | 5.26 |
| CHEMBL57004 | SITAMAQUINE | 2.0 | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4566866 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4467147 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4559932 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4448415 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 36100.0 | nM | 4.44 |