Assay Detail
ADMET
CHEMBL4394198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells assessed as reduction in cell viability measured after 48 hrs in presence of Staphylococcus saprophyticus nitroreductase and NADH by SRB assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.03 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473679 | — | — | 1 | 8.75 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 8.75 |
| CHEMBL4548007 | — | — | 1 | 8.74 |
| CHEMBL1868530 | — | — | 1 | 8.74 |
| CHEMBL4454897 | — | — | 1 | 7.84 |
| CHEMBL4577112 | — | — | 1 | 7.81 |
| CHEMBL421379 | — | — | 1 | 7.75 |
| CHEMBL4560417 | — | — | 1 | 7.52 |
| CHEMBL4543507 | — | — | 1 | 7.51 |
| CHEMBL123261 | — | — | 1 | 7.48 |
| CHEMBL4567423 | — | — | 1 | 7.43 |
| CHEMBL4560599 | — | — | 1 | 4.99 |
| CHEMBL4453333 | — | — | 1 | 4.97 |
| CHEMBL4449216 | — | — | 1 | 4.90 |
| CHEMBL4462402 | — | — | 1 | 4.77 |
| CHEMBL4542291 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473679 | — | IC50 | = | 1.793 | nM | 8.75 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 1.792 | nM | 8.75 |
| CHEMBL4548007 | — | IC50 | = | 1.806 | nM | 8.74 |
| CHEMBL1868530 | — | IC50 | = | 1.808 | nM | 8.74 |
| CHEMBL4454897 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4577112 | — | IC50 | = | 15.47 | nM | 7.81 |
| CHEMBL421379 | — | IC50 | = | 17.98 | nM | 7.75 |
| CHEMBL4560417 | — | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL4543507 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL123261 | — | IC50 | = | 33.43 | nM | 7.48 |
| CHEMBL4567423 | — | IC50 | = | 36.83 | nM | 7.43 |
| CHEMBL4560599 | — | IC50 | = | 10240.0 | nM | 4.99 |
| CHEMBL4453333 | — | IC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL4449216 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL4462402 | — | IC50 | = | 17110.0 | nM | 4.77 |
| CHEMBL4542291 | — | IC50 | = | 29120.0 | nM | 4.54 |