Assay Detail
Functional
CHEMBL4394427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC3 cells measured after 72 hrs by celltiter-glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.66 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537738 | — | — | 1 | 4.95 |
| CHEMBL4465197 | — | — | 1 | 4.91 |
| CHEMBL4439690 | — | — | 1 | 4.72 |
| CHEMBL4558865 | — | — | 1 | 4.66 |
| CHEMBL2137199 | — | — | 1 | 4.61 |
| CHEMBL4455520 | — | — | 1 | 4.51 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537738 | — | IC50 | = | 11140.0 | nM | 4.95 |
| CHEMBL4465197 | — | IC50 | = | 12360.0 | nM | 4.91 |
| CHEMBL4439690 | — | IC50 | = | 19250.0 | nM | 4.72 |
| CHEMBL4558865 | — | IC50 | = | 21840.0 | nM | 4.66 |
| CHEMBL2137199 | — | IC50 | = | 24820.0 | nM | 4.61 |
| CHEMBL4455520 | — | IC50 | = | 30880.0 | nM | 4.51 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 53380.0 | nM | 4.27 |