Assay Detail
Functional
CHEMBL4394429
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Antiproliferative activity against human C4-2B cells measured after 96 hrs by celltiter-glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.91 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465197 | — | — | 1 | 5.26 |
| CHEMBL4537738 | — | — | 1 | 5.04 |
| CHEMBL2137199 | — | — | 1 | 5.00 |
| CHEMBL4439690 | — | — | 1 | 4.98 |
| CHEMBL4558865 | — | — | 1 | 4.86 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 4.63 |
| CHEMBL4455520 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465197 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL4537738 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2137199 | — | IC50 | = | 10060.0 | nM | 5.00 |
| CHEMBL4439690 | — | IC50 | = | 10570.0 | nM | 4.98 |
| CHEMBL4558865 | — | IC50 | = | 13820.0 | nM | 4.86 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 23560.0 | nM | 4.63 |
| CHEMBL4455520 | — | IC50 | = | 23790.0 | nM | 4.62 |