Assay Detail
Functional
CHEMBL4394496
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Cytotoxicity against human RPMI8226/Cfzr cells after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy To Overcome Cancer Resistance to Carfilzomib and Bortezomib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.24 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451741 | — | — | 1 | 6.97 |
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 6.57 |
| CHEMBL4447840 | — | — | 1 | 6.51 |
| CHEMBL207990 | EPOXOMYCIN | — | 1 | 6.27 |
| CHEMBL3319605 | — | — | 1 | 5.67 |
| CHEMBL4459808 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451741 | — | IC50 | = | 106.2 | nM | 6.97 |
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4447840 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL207990 | EPOXOMYCIN | IC50 | = | 541.0 | nM | 6.27 |
| CHEMBL3319605 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4459808 | — | IC50 | = | 3410.0 | nM | 5.47 |