Assay Detail
ADMET
CHEMBL4394511
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Cytotoxicity against human WS1 cells measured after 72 hrs by alamar blue assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.89 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98248 | — | — | 1 | 5.54 |
| CHEMBL304929 | — | — | 1 | 5.36 |
| CHEMBL1092250 | — | — | 1 | 5.11 |
| CHEMBL4447797 | — | — | 1 | 5.07 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.07 |
| CHEMBL29197 | — | — | 1 | 5.01 |
| CHEMBL4443342 | — | — | 1 | 4.96 |
| CHEMBL1089203 | — | — | 1 | 4.92 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 4.89 |
| CHEMBL311959 | — | — | 1 | 4.85 |
| CHEMBL111038 | — | — | 1 | 4.85 |
| CHEMBL535429 | — | — | 1 | 4.68 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.64 |
| CHEMBL309682 | — | — | 1 | 4.55 |
| CHEMBL4446630 | — | — | 1 | 4.35 |
| CHEMBL4518437 | — | — | 1 | 4.31 |
| CHEMBL4468521 | — | — | 1 | - |
| CHEMBL4440586 | — | — | 1 | - |
| CHEMBL81073 | — | — | 1 | - |
| CHEMBL4467033 | — | — | 1 | - |
| CHEMBL4514780 | — | — | 1 | - |
| CHEMBL4462395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98248 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL304929 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1092250 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4447797 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL29197 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4443342 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1089203 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL554 | LAPATINIB | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL311959 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL111038 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL535429 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL939 | GEFITINIB | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL309682 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4446630 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4518437 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4468521 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4440586 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL81073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4467033 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4514780 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4462395 | — | IC50 | > | 50000.0 | nM | - |