Assay Detail
Functional
CHEMBL4394515
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Antiproliferative activity against human UCH12 cells measured after 72 hrs by alamar blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.69 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447797 | — | — | 1 | 5.26 |
| CHEMBL1092250 | — | — | 1 | 4.52 |
| CHEMBL311959 | — | — | 1 | 4.48 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 4.48 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
| CHEMBL304929 | — | — | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL98248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447797 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1092250 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL311959 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL554 | LAPATINIB | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL939 | GEFITINIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL304929 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL553 | ERLOTINIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL98248 | — | IC50 | > | 50000.0 | nM | - |