Assay Detail
Functional
CHEMBL4394935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.15 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573943 | — | — | 1 | 5.75 |
| CHEMBL4474354 | — | — | 1 | 5.51 |
| CHEMBL4533280 | — | — | 1 | 5.40 |
| CHEMBL4589605 | — | — | 1 | 5.34 |
| CHEMBL4538745 | — | — | 1 | 5.20 |
| CHEMBL4551633 | — | — | 1 | 5.18 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.15 |
| CHEMBL4440679 | — | — | 1 | 5.07 |
| CHEMBL4087968 | — | — | 1 | 4.96 |
| CHEMBL4535846 | — | — | 1 | 4.79 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 4.70 |
| CHEMBL4517397 | — | — | 1 | 4.70 |
| CHEMBL4531510 | — | — | 1 | - |
| CHEMBL4437698 | — | — | 1 | - |
| CHEMBL4443327 | — | — | 1 | - |
| CHEMBL4593455 | — | — | 1 | - |
| CHEMBL4547152 | — | — | 1 | - |
| CHEMBL4532680 | — | — | 1 | - |
| CHEMBL4577627 | — | — | 1 | - |
| CHEMBL4537439 | — | — | 1 | - |
| CHEMBL4521002 | — | — | 1 | - |
| CHEMBL4468169 | — | — | 1 | - |
| CHEMBL4532530 | — | — | 1 | - |
| CHEMBL4568740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573943 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4474354 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4533280 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4589605 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4538745 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL4551633 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL4440679 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL4087968 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL4535846 | — | IC50 | = | 16410.0 | nM | 4.79 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4517397 | — | IC50 | = | 20020.0 | nM | 4.70 |
| CHEMBL4531510 | — | IC50 | - | — | - | |
| CHEMBL4437698 | — | IC50 | - | — | - | |
| CHEMBL4443327 | — | IC50 | - | — | - | |
| CHEMBL4593455 | — | IC50 | - | — | - | |
| CHEMBL4547152 | — | IC50 | - | — | - | |
| CHEMBL4532680 | — | IC50 | - | — | - | |
| CHEMBL4577627 | — | IC50 | - | — | - | |
| CHEMBL4537439 | — | IC50 | - | — | - | |
| CHEMBL4521002 | — | IC50 | - | — | - | |
| CHEMBL4468169 | — | IC50 | - | — | - | |
| CHEMBL4532530 | — | IC50 | - | — | - | |
| CHEMBL4568740 | — | IC50 | - | — | - |