Assay Detail
Functional
CHEMBL4395365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei gambiense Feo reduction in parasite growth after 72 hrs by resazurin dye based fluorescence assay
93
Total Activities
93
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei gambiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei gambiense (CHEMBL613768) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei gambiense |
Publication
Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 93 | 5.68 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.82 |
| CHEMBL4567421 | — | — | 1 | 6.96 |
| CHEMBL4525222 | — | — | 1 | 6.85 |
| CHEMBL4584106 | — | — | 1 | 6.68 |
| CHEMBL4539329 | — | — | 1 | 6.64 |
| CHEMBL4573628 | — | — | 1 | 6.64 |
| CHEMBL4448818 | — | — | 1 | 6.42 |
| CHEMBL4534015 | — | — | 1 | 6.32 |
| CHEMBL4550734 | — | — | 1 | 6.29 |
| CHEMBL4590538 | — | — | 1 | 6.28 |
| CHEMBL4586951 | — | — | 1 | 6.26 |
| CHEMBL4444305 | — | — | 1 | 6.20 |
| CHEMBL4465788 | — | — | 1 | 6.19 |
| CHEMBL4516857 | — | — | 1 | 6.19 |
| CHEMBL4466415 | — | — | 1 | 6.18 |
| CHEMBL4542841 | — | — | 1 | 6.13 |
| CHEMBL4452686 | — | — | 1 | 6.13 |
| CHEMBL4548473 | — | — | 1 | 6.09 |
| CHEMBL4529689 | — | — | 1 | 6.07 |
| CHEMBL4464531 | — | — | 1 | 6.00 |
| CHEMBL4466329 | — | — | 1 | 6.00 |
| CHEMBL4465706 | — | — | 1 | 6.00 |
| CHEMBL4459419 | — | — | 1 | 5.93 |
| CHEMBL4461037 | — | — | 1 | 5.92 |
| CHEMBL4555640 | — | — | 1 | 5.87 |
| CHEMBL4575536 | — | — | 1 | 5.87 |
| CHEMBL4542097 | — | — | 1 | 5.87 |
| CHEMBL4575070 | — | — | 1 | 5.85 |
| CHEMBL4442067 | — | — | 1 | 5.85 |
| CHEMBL4553912 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4567421 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4525222 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4584106 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4539329 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4573628 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4448818 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4534015 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL4550734 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4590538 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4586951 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL4444305 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL4465788 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL4516857 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL4466415 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4542841 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL4452686 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4548473 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4529689 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4464531 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4466329 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4465706 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4459419 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4461037 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4542097 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4575536 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4555640 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4575070 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4442067 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4553912 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4534243 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4534866 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4513643 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4459719 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4453087 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4441230 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4547259 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4471985 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4455555 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4439331 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4469373 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4587856 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4440961 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4461800 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4560449 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4443875 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4449971 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4574851 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4518463 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4569425 | — | IC50 | = | 3600.0 | nM | 5.44 |