Assay Detail
Binding
CHEMBL4395512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate incubated for 15 mins by malachite green dye based pyrophosphatase coupled colorimetric assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Oxidized purine nucleoside triphosphate hydrolase (CHEMBL3708265) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ligand retargeting by binding site analogy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.69 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3782004 | — | — | 1 | 8.30 |
| CHEMBL4561244 | — | — | 1 | 7.52 |
| CHEMBL4446950 | — | — | 1 | 6.40 |
| CHEMBL4541864 | — | — | 1 | 6.10 |
| CHEMBL4589188 | — | — | 1 | 5.96 |
| CHEMBL4448755 | — | — | 1 | 4.77 |
| CHEMBL1232596 | — | — | 1 | 4.64 |
| CHEMBL1221922 | — | — | 1 | 4.55 |
| CHEMBL305513 | — | — | 1 | 4.36 |
| CHEMBL404150 | — | — | 1 | 4.34 |
| CHEMBL4476663 | — | — | 1 | - |
| CHEMBL389685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3782004 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4561244 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4446950 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4541864 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4589188 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4448755 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1232596 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1221922 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL305513 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL404150 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4476663 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL389685 | — | IC50 | = | 132000.0 | nM | - |