Assay Detail
Binding
CHEMBL4396182
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Displacement of [3H] batrachotoxinin from rat sodium channel site 2 measured after 60 mins by scintillation counter method
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.16 | 7.00 |
| IC50 | 3 | 6.10 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579120 | — | — | 2 | 7.00 |
| CHEMBL4562303 | — | — | 2 | 6.39 |
| CHEMBL439496 | VERATRIDINE | — | 2 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579120 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4579120 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4562303 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL4562303 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL439496 | VERATRIDINE | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL439496 | VERATRIDINE | IC50 | = | 8900.0 | nM | 5.05 |