Assay Detail
Functional
CHEMBL4396187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Mino cells measured after 72 hrs by CellTiter96 Aqueous non-radioactive cell proliferation assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.13 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170596 | — | — | 1 | 9.40 |
| CHEMBL4561814 | — | — | 1 | 9.30 |
| CHEMBL4450303 | — | — | 1 | 8.96 |
| CHEMBL4460679 | — | — | 1 | 8.72 |
| CHEMBL4444776 | — | — | 1 | 8.64 |
| CHEMBL4452441 | — | — | 1 | 8.62 |
| CHEMBL4556560 | — | — | 1 | 8.59 |
| CHEMBL4560291 | — | — | 1 | 8.54 |
| CHEMBL4546344 | — | — | 1 | 8.54 |
| CHEMBL4468193 | — | — | 1 | 8.48 |
| CHEMBL4462529 | — | — | 1 | 8.48 |
| CHEMBL4547014 | — | — | 1 | 8.47 |
| CHEMBL4441160 | — | — | 1 | 8.43 |
| CHEMBL4557569 | — | — | 1 | 8.38 |
| CHEMBL4449292 | — | — | 1 | 8.37 |
| CHEMBL4452045 | — | — | 1 | 8.22 |
| CHEMBL4573140 | — | — | 1 | 8.20 |
| CHEMBL4530925 | — | — | 1 | 8.19 |
| CHEMBL4445126 | — | — | 1 | 8.13 |
| CHEMBL4454179 | — | — | 1 | 8.10 |
| CHEMBL4461449 | — | — | 1 | 7.94 |
| CHEMBL4570238 | — | — | 1 | 7.78 |
| CHEMBL4578383 | — | — | 1 | 7.55 |
| CHEMBL4556518 | — | — | 1 | 7.52 |
| CHEMBL4443491 | — | — | 1 | 7.45 |
| CHEMBL4469683 | — | — | 1 | 7.00 |
| CHEMBL3989927 | IBERDOMIDE | 3.0 | 1 | 6.95 |
| CHEMBL4465530 | — | — | 1 | 6.80 |
| CHEMBL4554197 | — | — | 1 | 6.03 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170596 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4561814 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4450303 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4460679 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4444776 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4452441 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4556560 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4560291 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4546344 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4468193 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4462529 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4547014 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4441160 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4557569 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4449292 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4452045 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4573140 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4530925 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4445126 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4454179 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4461449 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL4570238 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL4578383 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL4556518 | — | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL4443491 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL4469683 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3989927 | IBERDOMIDE | IC50 | = | 111.6 | nM | 6.95 |
| CHEMBL4465530 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4554197 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL848 | LENALIDOMIDE | IC50 | > | 20000.0 | nM | - |
| CHEMBL4528248 | — | IC50 | > | 20000.0 | nM | - |