Assay Detail
Functional
CHEMBL4396188
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Antiproliferative activity against human MM1S cells measured after 168 hrs by CellTiter96 Aqueous non-radioactive cell proliferation assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.85 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170596 | — | — | 1 | 9.52 |
| CHEMBL4468193 | — | — | 1 | 9.40 |
| CHEMBL4546344 | — | — | 1 | 9.40 |
| CHEMBL4560291 | — | — | 1 | 9.22 |
| CHEMBL4449292 | — | — | 1 | 9.05 |
| CHEMBL4556560 | — | — | 1 | 9.05 |
| CHEMBL4465530 | — | — | 1 | 8.96 |
| CHEMBL4573140 | — | — | 1 | 8.96 |
| CHEMBL4444776 | — | — | 1 | 8.96 |
| CHEMBL4452441 | — | — | 1 | 8.96 |
| CHEMBL4461449 | — | — | 1 | 8.96 |
| CHEMBL4441160 | — | — | 1 | 8.89 |
| CHEMBL4454179 | — | — | 1 | 8.85 |
| CHEMBL4570238 | — | — | 1 | 8.74 |
| CHEMBL4554197 | — | — | 1 | 8.68 |
| CHEMBL4556518 | — | — | 1 | 8.54 |
| CHEMBL3989927 | IBERDOMIDE | 3.0 | 1 | 7.89 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170596 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4468193 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4546344 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4560291 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4449292 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4556560 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4465530 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4573140 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4444776 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4452441 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4461449 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4441160 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4454179 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4570238 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4554197 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4556518 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3989927 | IBERDOMIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 50.0 | nM | 7.30 |