Assay Detail
Functional
CHEMBL4396193
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Antiproliferative activity against human U266 cells measured after 72 hrs by CellTiter96 Aqueous non-radioactive cell proliferation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-266 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170596 | — | — | 1 | 8.70 |
| CHEMBL4556560 | — | — | 1 | 8.59 |
| CHEMBL4546344 | — | — | 1 | 8.25 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | - |
| CHEMBL4444776 | — | — | 1 | - |
| CHEMBL4441160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170596 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4556560 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4546344 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL848 | LENALIDOMIDE | IC50 | > | 20000.0 | nM | - |
| CHEMBL4444776 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4441160 | — | IC50 | > | 20000.0 | nM | - |