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Assay Detail

CHEMBL4396237

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations.
Zhou Y, Tao P, Wang M, Xu P, Lu W, Lei P, You Q.
Eur J Med Chem (2019) 177 : 105 -115
PubMed 31129449 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.16 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4065858 1 6.44
CHEMBL1436155 1 5.24
CHEMBL1559855 1 5.11
CHEMBL1440413 1 4.83
CHEMBL1611057 1 4.72
CHEMBL4450110 1 4.64
CHEMBL4556559 1 -
CHEMBL4577089 1 -
CHEMBL4475383 1 -
CHEMBL4441804 1 -
CHEMBL4476280 1 -
CHEMBL4454634 1 -
CHEMBL4461387 1 -
CHEMBL4515658 1 -
CHEMBL4445248 1 -
CHEMBL4462982 1 -
CHEMBL4583436 1 -
CHEMBL4441824 1 -
CHEMBL1256289 SODIUM OXAMATE 1 -
CHEMBL1554905 1 -
CHEMBL1888862 1 -
CHEMBL4515017 1 -
CHEMBL1555353 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4065858 IC50 = 360.0 nM 6.44
CHEMBL1436155 IC50 = 5700.0 nM 5.24
CHEMBL1559855 IC50 = 7800.0 nM 5.11
CHEMBL1440413 IC50 = 14700.0 nM 4.83
CHEMBL1611057 IC50 = 18900.0 nM 4.72
CHEMBL4450110 IC50 = 22700.0 nM 4.64
CHEMBL4556559 IC50 > 50000.0 nM -
CHEMBL4577089 IC50 > 50000.0 nM -
CHEMBL4475383 IC50 > 50000.0 nM -
CHEMBL4441804 IC50 > 50000.0 nM -
CHEMBL4476280 IC50 > 50000.0 nM -
CHEMBL4454634 IC50 > 50000.0 nM -
CHEMBL4461387 IC50 > 50000.0 nM -
CHEMBL4515658 IC50 > 50000.0 nM -
CHEMBL4445248 IC50 > 50000.0 nM -
CHEMBL4462982 IC50 > 50000.0 nM -
CHEMBL4583436 IC50 > 50000.0 nM -
CHEMBL4441824 IC50 > 50000.0 nM -
CHEMBL1256289 SODIUM OXAMATE IC50 = 45800000.0 nM -
CHEMBL1554905 IC50 > 50000.0 nM -
CHEMBL1888862 IC50 > 50000.0 nM -
CHEMBL4515017 IC50 > 50000.0 nM -
CHEMBL1555353 IC50 > 50000.0 nM -