Assay Detail
Binding
CHEMBL4396483
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Mixed inhibition of electric eel AChE using acetylcholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every minute for 30 mins by Lineweaver-Burk plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.43 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 6.27 |
| CHEMBL4465285 | — | — | 1 | 6.14 |
| CHEMBL4453275 | — | — | 1 | 5.71 |
| CHEMBL4451866 | — | — | 1 | 5.07 |
| CHEMBL4534747 | — | — | 1 | 5.05 |
| CHEMBL4522942 | — | — | 1 | 4.92 |
| CHEMBL4515971 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL4465285 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL4453275 | — | Ki | = | 1970.0 | nM | 5.71 |
| CHEMBL4451866 | — | Ki | = | 8550.0 | nM | 5.07 |
| CHEMBL4534747 | — | Ki | = | 8820.0 | nM | 5.05 |
| CHEMBL4522942 | — | Ki | = | 11890.0 | nM | 4.92 |
| CHEMBL4515971 | — | Ki | = | 14210.0 | nM | 4.85 |