Assay Detail
Binding
CHEMBL4397275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of humanized C57bl/6 mouse PDE4D7 UCR1 S129D mutant using cAMP as substrate by yeast myokinase/pyruvate kinase/lactate dehydrogenase-coupled fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.88 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541964 | ZATOLMILAST | 3.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541964 | ZATOLMILAST | IC50 | = | 133.0 | nM | 6.88 |