Assay Detail
Binding
CHEMBL4397308
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Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological Chaperones for the Treatment of α-Mannosidosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.06 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435118 | — | — | 1 | 6.30 |
| CHEMBL4457217 | — | — | 1 | 6.30 |
| CHEMBL4518572 | — | — | 1 | 6.30 |
| CHEMBL4475419 | — | — | 1 | 6.30 |
| CHEMBL4462117 | — | — | 1 | 6.30 |
| CHEMBL4465842 | — | — | 1 | 6.30 |
| CHEMBL4471561 | — | — | 1 | 5.50 |
| CHEMBL4483772 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435118 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4457217 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4518572 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4475419 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4462117 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4465842 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4471561 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL4483772 | — | Ki | = | 7000.0 | nM | 5.16 |