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Assay Detail

CHEMBL4397637

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human CTRPA cells harboring APC A1309 mutant after 72 hrs by Celltiter-Glo assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).
Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK.
J Med Chem (2019) 62 : 5217 -5241
PubMed 31070915 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 8.61 10.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4544901 1 10.40
CHEMBL4453433 1 9.22
CHEMBL4474102 1 9.15
CHEMBL4515879 1 9.15
CHEMBL4525195 1 9.10
CHEMBL4448361 1 9.05
CHEMBL4560611 1 9.03
CHEMBL4523058 1 8.92
CHEMBL4475554 1 8.82
CHEMBL4517283 1 8.80
CHEMBL4456428 1 8.55
CHEMBL4454239 1 8.49
CHEMBL4439001 1 8.47
CHEMBL4459807 1 8.47
CHEMBL4470755 1 8.47
CHEMBL4473186 1 8.42
CHEMBL4467851 1 8.37
CHEMBL4566608 1 8.16
CHEMBL4518689 1 8.09
CHEMBL4464611 1 8.02
CHEMBL4448984 1 7.99
CHEMBL4530619 1 7.98
CHEMBL4514756 1 6.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4544901 IC50 = 0.04 nM 10.40
CHEMBL4453433 IC50 = 0.6 nM 9.22
CHEMBL4474102 IC50 = 0.7 nM 9.15
CHEMBL4515879 IC50 = 0.7 nM 9.15
CHEMBL4525195 IC50 = 0.8 nM 9.10
CHEMBL4448361 IC50 = 0.9 nM 9.05
CHEMBL4560611 IC50 = 0.94 nM 9.03
CHEMBL4523058 IC50 = 1.2 nM 8.92
CHEMBL4475554 IC50 = 1.5 nM 8.82
CHEMBL4517283 IC50 = 1.6 nM 8.80
CHEMBL4456428 IC50 = 2.8 nM 8.55
CHEMBL4454239 IC50 = 3.2 nM 8.49
CHEMBL4439001 IC50 = 3.4 nM 8.47
CHEMBL4459807 IC50 = 3.4 nM 8.47
CHEMBL4470755 IC50 = 3.4 nM 8.47
CHEMBL4473186 IC50 = 3.8 nM 8.42
CHEMBL4467851 IC50 = 4.3 nM 8.37
CHEMBL4566608 IC50 = 6.9 nM 8.16
CHEMBL4518689 IC50 = 8.2 nM 8.09
CHEMBL4464611 IC50 = 9.6 nM 8.02
CHEMBL4448984 IC50 = 10.2 nM 7.99
CHEMBL4530619 IC50 = 10.5 nM 7.98
CHEMBL4514756 IC50 = 122.0 nM 6.91