Assay Detail
Binding
CHEMBL4397899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.91 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4532140 | — | — | 1 | 7.01 |
| CHEMBL4543264 | — | — | 1 | 6.89 |
| CHEMBL4527894 | — | — | 1 | 6.62 |
| CHEMBL4592339 | — | — | 1 | 6.60 |
| CHEMBL4520636 | — | — | 1 | 6.57 |
| CHEMBL4556365 | — | — | 1 | 6.29 |
| CHEMBL4466435 | — | — | 1 | 6.19 |
| CHEMBL4443701 | — | — | 1 | 6.16 |
| CHEMBL4536368 | — | — | 1 | 6.09 |
| CHEMBL4445498 | — | — | 1 | 5.43 |
| CHEMBL4572934 | — | — | 1 | 5.37 |
| CHEMBL4440925 | — | — | 1 | 4.68 |
| CHEMBL4525913 | — | — | 1 | 4.58 |
| CHEMBL4455732 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4532140 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4543264 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4527894 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4592339 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4520636 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4556365 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4466435 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4443701 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4536368 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4445498 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL4572934 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4440925 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4525913 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL4455732 | — | IC50 | = | 58500.0 | nM | 4.23 |