Assay Detail
Binding
CHEMBL4398306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DENV2 NS2B-NS3 serine protease expressed using Benzoyl-Nle-Lys-Arg-Arg-AMC as substrate measured preincubated for 3 mins followed by substrate addition by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent update on anti-dengue drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.86 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 6.19 |
| CHEMBL1458891 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1458891 | — | IC50 | = | 2940.0 | nM | 5.53 |