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Assay Detail

CHEMBL4398308

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Functional
Antiviral activity against DENV2
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 2
Confidence 1 — Organism
Curated By Autocuration

Target

dengue virus type 2 (CHEMBL613966)
Type ORGANISM
Organism dengue virus type 2

Publication

Recent update on anti-dengue drug discovery.
Dighe SN, Ekwudu O, Dua K, Chellappan DK, Katavic PL, Collet TA.
Eur J Med Chem (2019) 176 : 431 -455
PubMed 31128447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 5.71 7.06
IC50 3 4.88 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL728 PROCHLORPERAZINE 4.0 1 7.06
CHEMBL4456898 1 5.62
CHEMBL1277682 ISOMAMMEIGIN 1 5.58
CHEMBL1689183 1 5.58
CHEMBL4575134 1 5.58
CHEMBL4469548 1 5.55
CHEMBL4587495 1 5.50
CHEMBL584 NELFINAVIR 4.0 1 5.46
CHEMBL4449109 1 5.24
CHEMBL445740 BETA-CARYOPHYLLENE 1.0 1 4.66
CHEMBL1080997 CITRAL 1 4.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL728 PROCHLORPERAZINE EC50 = 88.0 nM 7.06
CHEMBL4456898 EC50 = 2400.0 nM 5.62
CHEMBL1277682 ISOMAMMEIGIN EC50 = 2600.0 nM 5.58
CHEMBL1689183 EC50 = 2600.0 nM 5.58
CHEMBL4575134 EC50 = 2600.0 nM 5.58
CHEMBL4469548 EC50 = 2800.0 nM 5.55
CHEMBL4587495 EC50 = 3200.0 nM 5.50
CHEMBL584 NELFINAVIR IC50 = 3500.0 nM 5.46
CHEMBL4449109 EC50 = 5700.0 nM 5.24
CHEMBL445740 BETA-CARYOPHYLLENE IC50 = 22000.0 nM 4.66
CHEMBL1080997 CITRAL IC50 = 31000.0 nM 4.51