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Assay Detail

CHEMBL4398337

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Functional
Antiviral activity against dengue virus
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Dengue virus
Confidence 1 — Organism
Curated By Autocuration

Target

Dengue virus (CHEMBL613757)
Type ORGANISM
Organism Dengue virus

Publication

Recent update on anti-dengue drug discovery.
Dighe SN, Ekwudu O, Dua K, Chellappan DK, Katavic PL, Collet TA.
Eur J Med Chem (2019) 176 : 431 -455
PubMed 31128447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 5.65 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL251077 1 6.40
CHEMBL4436053 1 6.40
CHEMBL400092 LYCORINE 1 6.40
CHEMBL572497 1 6.40
CHEMBL4460577 1 5.41
CHEMBL4455964 1 4.95
CHEMBL508326 1 4.95
CHEMBL3740621 1 4.95
CHEMBL3740025 1 4.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL251077 EC50 = 400.0 nM 6.40
CHEMBL4436053 EC50 = 400.0 nM 6.40
CHEMBL400092 LYCORINE EC50 = 400.0 nM 6.40
CHEMBL572497 EC50 = 400.0 nM 6.40
CHEMBL4460577 EC50 = 3900.0 nM 5.41
CHEMBL4455964 EC50 = 11200.0 nM 4.95
CHEMBL508326 EC50 = 11200.0 nM 4.95
CHEMBL3740621 EC50 = 11200.0 nM 4.95
CHEMBL3740025 EC50 = 11200.0 nM 4.95