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Assay Detail

CHEMBL4398418

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Functional
Antiviral activity against DENV2 infected in BHK-21 cells assessed as viral replication after 24 to 48 hrs by luciferase reporter gene assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 2
Confidence 1 — Organism
Curated By Autocuration

Target

dengue virus type 2 (CHEMBL613966)
Type ORGANISM
Organism dengue virus type 2

Publication

Recent update on anti-dengue drug discovery.
Dighe SN, Ekwudu O, Dua K, Chellappan DK, Katavic PL, Collet TA.
Eur J Med Chem (2019) 176 : 431 -455
PubMed 31128447 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.97 5.97
IC90 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL682 AMODIAQUINE 4.0 2 5.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL682 AMODIAQUINE IC50 = 1080.0 nM 5.97
CHEMBL682 AMODIAQUINE IC90 = 2690.0 nM -