Assay Detail
Binding
CHEMBL4398459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCl-1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The chemical biology of apoptosis: Revisited after 17 years.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.21 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439276 | — | — | 1 | 9.72 |
| CHEMBL3393621 | — | — | 1 | 8.00 |
| CHEMBL1269107 | — | — | 1 | 7.60 |
| CHEMBL4519497 | — | — | 1 | 7.24 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.75 |
| CHEMBL408194 | OBATOCLAX | 3.0 | 1 | 5.70 |
| CHEMBL551288 | APOGOSSYPOL | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439276 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL3393621 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL1269107 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4519497 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL408194 | OBATOCLAX | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL551288 | APOGOSSYPOL | Ki | = | 3350.0 | nM | 5.47 |