Assay Detail
Functional
CHEMBL4398495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Photodynamic cytotoxicity against human A549 cells assessed as reduction in cell viability preincubated for 24 hrs followed by compound washout and subsequent 650 nanometer laser light irradiation at 1 J/cm2 measured by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The photodynamic activities of dimethyl 13<sup>1</sup>-[2-(guanidinyl)ethylamino] chlorin e<sub>6</sub> photosensitizers in A549 tumor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.19 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551107 | — | — | 1 | 6.40 |
| CHEMBL500576 | TEMOPORFIN | 4.0 | 1 | 6.11 |
| CHEMBL4582691 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4551107 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL500576 | TEMOPORFIN | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL4582691 | — | IC50 | = | 886.0 | nM | 6.05 |